3 epigenetic aberrations as potential causes of the paternal age effects sexual differences and the loss of brain laterali
Báo cáo khoa học: Levels of mTOR and its downstream targets 4E-BP1, eEF2, and eEF2 kinase in relationships with tau in Alzheimer’s disease brain doc
Ngày tải lên :
16/03/2014, 22:20
... levels of p-mTOR (Ser2448) was obviously increased in of cases of the medial temporal cortex staged at IV, V and VI according to Braak and Braak criteria as compared with cases staged at 0, I and ... weak staining in the granule layers of the dentate gyrus (not shown) In contrast, in control brain slices there was weak stainings in the pyramidal neurons of the CA1, CA2, CA3 and the entorhinal ... out to understand the pathogenesis of the NFTs in AD in the past two decades, none has ever analysed the possible changes of various controlling factors of protein translation such as mTOR, 4E-BP1,...
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báo cáo hóa học: " Maximal COX-2 and ppRb expression in neurons occurs during early Braak stages prior to the maximal activation of astrocytes and microglia in Alzheimer''''s disease" pdf
Ngày tải lên :
19/06/2014, 22:20
... in the design of the study and helped to draft the manuscript All authors read and approved the final manuscript Acknowledgements The authors thank the Netherlands Brain Bank for supplying the ... represents the interquartile range that contains 50% of the values The whiskers extend from the box to the highest and lowest values The line across the box indicates the median Kruskall-Wallis test was ... expression of COX-2 and ppRb would be associated with increased presence and activation of glial cells Using post mortem brain tissue we have investigated whether activation/occurrence of microglia and...
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báo cáo hóa học: " Peripheral reductive capacity is associated with cognitive performance and survival in Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... measurement of a set of individual anti-oxidant species The anti-oxidant activity measured by the AOC assay is the net result of the contribution of all the individual anti-oxidants, of their interactions ... related to the age of the subjects To investigate the possible relationship between serum AOC and cognitive deficit, we used the MMSE scores as proxy of status (control vs AD) and of disease progression ... increasing the flexibility of the anti-oxidant defence system to react to unfavourable conditions Decreases in the levels or activities of anti-oxidant enzymes, such as SOD and GPx, and of both...
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Tài liệu Báo cáo khoa học: Animal models of amyloid-b-related pathologies in Alzheimer’s disease docx
Ngày tải lên :
16/02/2014, 09:20
... microgliosis and astrocytosis The Dutch and Iowa mutations both reduce the negative charge of Ab and stimulate the formation of amyloid fibrils and attachment to the cell surface of human cerebrovascular ... APP23 and humans to the sum of Ab1–40 and Ab1–42, and in tgArcSwe they refer to Ab1–40 A density gÆL)1 for brain tissue has been assumed when the ratio of brain Ab ⁄ plasma Ab has been calculated ... between the plasma and central nervous system (brain and CSF) [105] If so, the ratio of [Ab ]brain ⁄ [Ab]plasma or [Ab]CSF ⁄ [Ab]plasma should be the same in all transgenic models A much higher plasma...
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Psychiatric and Cognitive Disorders in Parkinson’s Disease pptx
Ngày tải lên :
28/03/2014, 22:21
... progression along the stages of the illness There is also speciWc discussion of the diVerent clinical complications that may emerge during the evolution of the disease and the subtypes of the illness ... Mechanisms of PD Before discussing the potential mechanisms of PD, we will brieXy review the anatomy and physiology of the basal ganglia, as well as the pharmacology of dopamine receptors The basal ... comprehensive account of these aspects of Parkinson’s disease, based on the neurologic and psychiatric assessment of hundreds of patients by the authors It also oVers a thorough survey of the published...
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báo cáo hóa học: " Using animal models to determine the significance of complement activation in Alzheimer''''s disease" pptx
Ngày tải lên :
19/06/2014, 22:20
... [52], and the increased neuronal loss in the APP/sCrry mouse may be due to decreased production of C3a as well as the opsonin, C3b However, whether inhibition of complement activation in the AD brain ... at months of age, and increases with age; total Aβ burden peaks at one year of age, although the percentage of Aβ that is fibrillar (thioflavin-S reactive) increases up to years of age Matsuoka ... in the brains of most aged primates, with a few exceptions The brain of the aged baboon contains phosphorylated tau protein [147,148], and an age- related accumulation of tau also occurs in the...
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báo cáo hóa học: " The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer''''s disease" ppt
Ngày tải lên :
19/06/2014, 22:20
... that the interaction of Aβ with microglia and the assembly of the active microglial NADPH oxidase maybe largely responsible for the oxidative damage observed in the AD brain Astrocytes and the ... as the tyrosine kinase Syk [30,32,52] Activation of these signaling cascades are linked to the synthesis and secretion of proinflammatory molecules and cytokines [28,30,52-58] Microglia and the ... peroxynitrite and other oxidants [33] The excessive production of these free radicals can damage tissue adjacent to the sites of inflammatory action; therefore, the activation of the NADPH oxidase is...
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báo cáo hóa học: " Neuroinflammation in Alzheimer’s disease wanes with age" pdf
Ngày tải lên :
19/06/2014, 22:20
... association between age of death and the area density of KP1, CR3/43 and GFAP in AD cases and controls, regression analysis was performed The occurrence of KP1, CR3/43 and GFAP rapidly decreases ... earlier age at onset [17] The hypothesised frequency distribution of the association between age at onset and the presence of APOE4 would therefore suggest that the occurrence of APOE4 decreases ... Methods Case selection Post-mortem brain material was obtained from the Netherlands Brain Bank (Amsterdam, The Netherlands) All donors or their next of kin provided written informed consent for brain...
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Báo cáo y học: "Phenomenology and management of cognitive and behavioral disorders in Parkinson''''s disease. Rise and logic of dementia in Parkinson''''s disease" pptx
Ngày tải lên :
08/08/2014, 21:20
... stages of parkinsonism, absence of standard definition of PD itself) may be another cause for discrepancies [36] James Parkinson had noted that the problem was one of classification: "The disease, ... distinct from senile dementia of the Alzheimer type, and 3) a severe form of dementia showing neuropathological changes in the basal ganglia and in the cortex, the latter of the Alzheimer type This ... that, further in his book, James Parkinson admitted that: "as the debility increases and the influence of the will over the muscles fades away, the tremulous agitation becomes more vehement" Therefore,...
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Memory performance in healthy elderly without Alzheimer’s disease: effects of time and apolipoprotein-E pptx
Ngày tải lên :
05/03/2014, 21:20
... Please note The intervals on the X axis represent the average time of follow-up assessments after baseline These are smoothed regression lines that depict the differences in the slope of performance ... visuospatial and tests of reasoning were the main contributors These included the Rosen Drawing Test [45], matching and recognition components of the Benton Visual Retention Test [4] and the Identities and ... Language was evaluated using the Boston Naming Test [32], the Controlled Word Association test [3], category naming, the Complex Ideational Material Subtest and the repetition of phrases from the...
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PET in the Evaluation of Alzheimer’s Disease and Related Disorders docx
Ngày tải lên :
05/03/2014, 23:20
... barrier, as well as across the membrane of cells in the brain, reducing the statistical count quality of the image); and placing the patient’s brain symmetrically with respect to the plane of the ... however, the MMSE or assessments of delayed recall fall outside of the normal range for age and education, then the patient may have either MCI or dementia The distinction of MCI versus dementia is often ... looking for tilt of the long axis of the brain away from the vertical, and with respect to out -of- plane rotation by examining structures below where most of the brain tissue lies, such as the photopenia...
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báo cáo hóa học: " Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer''''s disease" potx
Ngày tải lên :
19/06/2014, 22:20
... Density and Aβ-Positive Object Area Ratio These were calculated by determining the sum of the numbers of Aβ-positive objects (or the sum of the areas of the Aβ positive objects) for the entire ... oligomers as the immunogen than other amyloid conformations The experiments described here were also designed to assess the effect of immunization of animals at an advanced age/ stage of pathology on the ... ages, a decrease in the accumulation of both fibrillar and diffuse amyloid plaques occurs only when mice are immunized at early stages of the disease (12–16 months of age) The level of C3 activation...
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báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx
Ngày tải lên :
19/06/2014, 22:20
... Acknowledgements We thank the participants in the Rush Memory and Aging Project and their families, as well as the staff of the Rush Alzheimer’s Disease Center This study was supported by an Oakland University-Beaumont ... until the standard curve OD reached 1.0 Softmax Pro software version 3.0 (Molecular Devices) was used to generate the best-fit plot of the standard curve, using the log-logit option Calculation of ... Tris base (21.8 mg) was added to bring the Tris concentration to 100 mM, and 3.8 μl of 12.1 N HCl was added to adjust the pH to 8.8 The preparation was centrifuged (11,752 × g, min), passed through...
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báo cáo hóa học: " Osteoarthritis accelerates and exacerbates Alzheimer’s disease pathology in mice" ppt
Ngày tải lên :
19/06/2014, 22:20
... induction of osteoarthritis in the APP/PS1 mouse model of AD at months of age resulted in the development of Ab plaques and neuroinflammation as early as months of age, whereas there was lack of Ab ... increase in the number of small plaques throughout the brain parenchyma In contrast, the increase of large plaques (> 100 μm) was much higher, especially in the middle and posterior third of the brain ... anterior portion of the brain, the next sections the middle and the last sections represented the posterior third of the brain in our cell counting The knees and temporomandibular joints were also...
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Báo cáo y học: "rug discovery from Chinese medicine against neurodegeneration in Alzheimer’s and vascular dementia" pdf
Ngày tải lên :
13/08/2014, 14:20
... patients had a history of stroke [8] As there is no cure for VaD, management of VaD emphasizes on the prevention of new stroke and control of vascular risk factors Dementia and Chinese medicine ... for the Diagnosis, Differentiation of Syndrome and Evaluation of Efficacy of Vascular Dementia for Research Studies were published on 2002, emphasizing that the diagnosis of VaD must meet the ... often not use any Chinese medicine theory as the basis for their investigation when studying these compounds Therefore, some Chinese medicine experts are skeptical about the approach [33] Standardized...
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Báo cáo y học: "Alternative ion channel splicing in mesial temporal lobe epilepsy and Alzheimer''''s disease" pot
Ngày tải lên :
14/08/2014, 18:20
... we show both the presence of the two transcript forms and the effects of the disease state on reducing the variant splice form of CLCN7 (Figure 1c) Alzheimer's disease For AD, 1,479 potential splicing ... lists of disease-associated ion channel alternative splicing events comes the task of deciphering the functional consequences of these changes and how they may contribute to the diseases There are ... transcript was studied in Xenopus oocytes in the presence of α subunits The protein encoded by the splice variant inactivated at a faster rate and the voltage dependence of the α/β complex was shifted...
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SKKN -Làm việc theo cặp hoặc tổ (nhóm) - áp dụng cho sách giáo khoa tiếng Anh 7 (pair work and group work in grade 7)
Ngày tải lên :
31/03/2015, 10:47
... in pairs, please Nguyễn Bỉnh Khiêm chia lớp +Work in pairs, please thành nhóm dễ dàng +Can you go into works, please lớp có phân chia thành tổ, +In fours (in groups of four) please tổ thành nhóm ... like everybody to find out the key Một số câu lệnh sau thay cử kết hợp lời nói với cử : + No ! That’s not clear Let’s it again + Be quiet and listen ! + All of you, together ! + It’s Hoa first Now ... Everyone, listen and repeat ! d) Cử : + Come on You ! Sử dụng cử (gesture) + You, please! điều khiển tổ chức lớp học chia Topic : Pair work and group work in grade + In halves, you first, then you !...
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Relationship between stock return and trading volume in vietnam's stock market
Ngày tải lên :
27/09/2013, 21:58
... they emphasized the interaction of GARCH and volume effects, and the impact of firm size and trading volume on these effects for individual stocks of the Australian All Ordinaries Index They concluded ... First, there is the feedback relation between return of two markets and the same result for the volume between them Second, the return of one market does Granger cause the volume of the other Again, ... answer the important question of whether the linkage of volume, return and volatility in the case of Vietnam market at both market level and firm level exists 1.4 RESEARCH OBJECTIVES AND QUESTIONS...
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Tài liệu Alzheimer’s Disease and Other Dementias doc
Ngày tải lên :
14/02/2014, 18:20
... atrophy, or withering of brain cells on the cortex (the surface of the brain) , indicates that the brain has shrunk WHAT IS THE BASIS FOR THE DIAGNOSIS? To be diagnosed with dementia, the patient ... functioning These cognitive problems reflect damage to the cortex of the brain, which processes information from other parts of the brain as well as from various parts of the body and peripheral ... affected by dementias are located both in the outer layers of the brain, the cortex, and in deeper structures of the brain The cerebral cortex is the area of the brain where many cognitive functions...
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